Malazan Empire: Dadding - Viewing Profile - Malazan Empire

Gene Wolfe's Book of the New Sun series straddles the line between Fantasy and Science Fiction, some of it being set in space. It's a challenging series, but very rewarding.

Cause, on 24 March 2020 - 05:53 PM, said:

Disclosure: I am not a doctor. I am a microbiologist. Don't take any drugs unless your doctor tells you to.


The earliest paper that talked about chloroquine treatment for SARS-CoV-2 that I can find is this one from Nature. They tried 5 already-on-the-market drugs that various groups had shown had some antiviral activity. Chloroquine specifically had been shown to do 2 things: 1) Mess with the pH of compartments inside the cell that viruses often manipulate to gain entry into our cells. 2) Mess with some of the 'decoration' of receptors that are recognized by viruses. It's also just generally got widespread low-level effects on the immune system, which they thought might also come in handy. This group showed it was a useful drug for combatting SARS-CoV-2 in cells (in-vitro), which was later backed up by a small amount of data in people (in-vivo).

When Zika happened a while back, some antibiotics in a class called "macrolides" (which includes azithromycin) were shown to have some antiviral effects too. I haven't done an extensive literature on that subject, and I don't think anybody has a really definitive answer as to why macrolides are antiviral despite being antibiotics that are traditionally used to fight off bacteria (specifically these types target the protein-making-factories of bacteria, but not the human equivalents). A quick search shows me that macrolides might be antiviral because they mess with some proteins in the internalization pathway in human cells, that viruses often hijack or subvert. But drugs can often have complicated pharmacokinetic interactions that we don't always immediately understand.

Here's a good summary of some of the data from a reputable source.

Beaver Killia, on 23 March 2020 - 03:27 AM, said:

It's really not that bad. I got tested almost two weeks ago (negative) and it was a tiny bit uncomfortable for a couple seconds, then I coughed, and then it was done.

Best decision I ever made: moving into a small apartment building with a gym. Don't need to leave my building so I actually feel like going, and go at 6:30AM so I never see anyone. 10/10 highly recommended.

Looking through BH, NoK and the Wiki says:

• Some of the larger estates are butted up against the cliff wall below Mock's Hold
• Some characters head south from Mock's Estate (presumably butted against that cliff wall) to arrive at Admiral Bridge
• Admiral Bridge leads to the Mouse Quarter
• The wall of Raven Hill Park curves southward, forming one side of the street leading to Admiral Bridge
• Old Orchard Wall goes west until it hits Raven Hill Road, then south to the hill itself. By skirting the hill on the East side along Old City Wall, you get to Admiral Bridge

So putting that together I got the following approximate location (red star):





Alternatively it could be more Eastward. One thing that I noticed in other Malazan maps like the Darujhistan map is that the District/Quarter distinctions are a bit fuzzy (it's unclear whether Lakefront extends along the entire Lakefront, or just the Lakefront East of River Foss for example). So the Mouse Quarter may also refer to a lot more land than just the separated chunk near the water.