Malazan Empire: Dadding - Viewing Profile - Malazan Empire

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User is offline Apr 27 2020 05:20 PM

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Member Title:
Shaved Knuckle in the Hole
Age Unknown
October 13
Halifax, Nova Scotia
Gaming, Reading, Science, Climbing

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  1. In Topic: I need suggestions

    31 March 2020 - 02:00 PM

    Gene Wolfe's Book of the New Sun series straddles the line between Fantasy and Science Fiction, some of it being set in space. It's a challenging series, but very rewarding.
  2. In Topic: COVID-19 (aka Coronavirus, aka 2019-nCoV)

    24 March 2020 - 06:37 PM

    View PostCause, on 24 March 2020 - 05:53 PM, said:

    Gorefest, mezla anyone else. So people in the us and Nigeria are already dying from misusing hydroxychloraquinone. Not surprising.

    I tell people who ask me about it that the trial was 30 people, no controls, no double blind and I wouldn't get my hopes up.

    What I can't for the life of me figure out is why the doctor who did the thirty people trial thought it would a drug worth trying in the first place, or mixing it with an antibiotic?

    Disclosure: I am not a doctor. I am a microbiologist. Don't take any drugs unless your doctor tells you to.

    The earliest paper that talked about chloroquine treatment for SARS-CoV-2 that I can find is this one from Nature. They tried 5 already-on-the-market drugs that various groups had shown had some antiviral activity. Chloroquine specifically had been shown to do 2 things: 1) Mess with the pH of compartments inside the cell that viruses often manipulate to gain entry into our cells. 2) Mess with some of the 'decoration' of receptors that are recognized by viruses. It's also just generally got widespread low-level effects on the immune system, which they thought might also come in handy. This group showed it was a useful drug for combatting SARS-CoV-2 in cells (in-vitro), which was later backed up by a small amount of data in people (in-vivo).

    When Zika happened a while back, some antibiotics in a class called "macrolides" (which includes azithromycin) were shown to have some antiviral effects too. I haven't done an extensive literature on that subject, and I don't think anybody has a really definitive answer as to why macrolides are antiviral despite being antibiotics that are traditionally used to fight off bacteria (specifically these types target the protein-making-factories of bacteria, but not the human equivalents). A quick search shows me that macrolides might be antiviral because they mess with some proteins in the internalization pathway in human cells, that viruses often hijack or subvert. But drugs can often have complicated pharmacokinetic interactions that we don't always immediately understand.

    Here's a good summary of some of the data from a reputable source.
  3. In Topic: COVID-19 (aka Coronavirus, aka 2019-nCoV)

    24 March 2020 - 04:05 PM

    View PostBeaver Killia, on 23 March 2020 - 03:27 AM, said:

    I'd happily shit in a bag rather then have that fucker stuck up my nose.

    Wonder how many people cat slap that thing away?

    It's really not that bad. I got tested almost two weeks ago (negative) and it was a tiny bit uncomfortable for a couple seconds, then I coughed, and then it was done.
  4. In Topic: What's messing with your groove?

    29 January 2020 - 01:40 PM

    Best decision I ever made: moving into a small apartment building with a gym. Don't need to leave my building so I actually feel like going, and go at 6:30AM so I never see anyone. 10/10 highly recommended.
  5. In Topic: Admiral bridge

    07 December 2019 - 05:31 PM

    Looking through BH, NoK and the Wiki says:

    • Some of the larger estates are butted up against the cliff wall below Mock's Hold
    • Some characters head south from Mock's Estate (presumably butted against that cliff wall) to arrive at Admiral Bridge
    • Admiral Bridge leads to the Mouse Quarter
    • The wall of Raven Hill Park curves southward, forming one side of the street leading to Admiral Bridge
    • Old Orchard Wall goes west until it hits Raven Hill Road, then south to the hill itself. By skirting the hill on the East side along Old City Wall, you get to Admiral Bridge
    So putting that together I got the following approximate location (red star):

    Posted Image

    Alternatively it could be more Eastward. One thing that I noticed in other Malazan maps like the Darujhistan map is that the District/Quarter distinctions are a bit fuzzy (it's unclear whether Lakefront extends along the entire Lakefront, or just the Lakefront East of River Foss for example). So the Mouse Quarter may also refer to a lot more land than just the separated chunk near the water.



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  1. Photo


    12 Oct 2019 - 19:57
    Happy birthday
  2. Photo


    22 Apr 2015 - 07:56
    My father was born in Wales and a few years back I decided to take a welsh language course. Can't remember much but the alphabet. Ever since I automatically read things as though they are in welsh. So, D is d, dd is th, f is v, ff is f, ll is...actually, not sure how to write that one, schl maybe?
  3. Photo


    22 Apr 2015 - 04:45
    I didn't write that well. I was meant to be asking if the dd is pronounced as dd (bedding) or th (as in bydd).
    You're right though, Dadding does sound like something fathers would do. Term for tell awful dad jokes, perhaps?
  4. Photo


    22 Apr 2015 - 03:50
    So, is it DaTHing or DADding? :)
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