Malazan Empire: COVID-19 (aka Coronavirus, aka 2019-nCoV) - Malazan Empire

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COVID-19 (aka Coronavirus, aka 2019-nCoV)

#3401 User is offline   Azath Vitr (D'ivers 

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Posted 12 September 2022 - 04:23 PM

'One of Long COVID's Worst Symptoms Is Also Its Most Misunderstood

Brain fog isn't like a hangover or depression. It's a disorder of executive function that makes basic cognitive tasks absurdly hard.

[....] worked in artificial intelligence and analyzed complex systems without hesitation, but now "runs into a mental wall" when faced with tasks as simple as filling out forms. Her memory, once vivid, feels frayed and fleeting. Former mundanities—buying food, making meals, cleaning up—can be agonizingly difficult. Her inner world—what she calls "the extras of thinking, like daydreaming, making plans, imagining"—is gone. The fog "is so encompassing, [...] it affects every area of my life." For more than 900 days, while other long-COVID symptoms have waxed and waned, her brain fog has never really lifted.

Of long COVID's many possible symptoms, brain fog "is by far one of the most disabling and destructive," [...] from the University of Oxford, told me. It's also among the most misunderstood. [...]

20 to 30 percent of patients report brain fog three months after their initial infection, as do 65 to 85 percent of the long-haulers who stay sick for much longer. It can afflict people who were never ill enough to need a ventilator—or any hospital care. And it can affect young people in the prime of their mental lives.

Long-haulers with brain fog say that it's like none of the things that people—including many medical professionals—jeeringly compare it to. It is more profound than the clouded thinking that accompanies hangovers, stress, or fatigue. [...] distinct from and worse than her experience with ADHD. It is not psychosomatic, and involves real changes to the structure and chemistry of the brain. It is not a mood disorder: "If anyone is saying that this is due to depression and anxiety, they have no basis for that, and data suggest it might be the other direction," [...]

[...] brain often loses focus mid-sentence[...] “I forget what I’m saying[...] stopped [...] from driving, because she’d forget her destination en route. For more than a year, she couldn’t read, either, because making sense of a series of words had become too difficult.'

What Makes Brain Fog So Unforgiving

This post has been edited by Azath Vitr (D'ivers: 12 September 2022 - 04:27 PM

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#3402 User is offline   QuickTidal 

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Posted 19 September 2022 - 07:31 PM

77 year old stepfather is in hospital with full blown COVID Pneumonia. No other updates yet. Went by ambulance yesterday when no one could move him as they arrived home from a friends place.
"When the last tree has fallen, and the rivers are poisoned, you cannot eat money, oh no." ~Aurora
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#3403 User is offline   QuickTidal 

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Posted 20 September 2022 - 06:50 PM

...and now of course my mom has COVID....complicated by her cancer I fear for her now as her immune system is really weak.

She sounds like she always does when she has a bad cold, but still.

I told her that if she spikes a fever or has trouble breathing to call 911 and go to the hospital.

I'm terrified for her.
"When the last tree has fallen, and the rivers are poisoned, you cannot eat money, oh no." ~Aurora
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#3404 User is offline   Mezla PigDog 

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Posted 20 September 2022 - 08:54 PM

Good luck QT. You hear lots of stories about vulnerable people sailing through a bout of covid. Remember that the bad outcomes are the outliers. But of course you don't know for sure anyone will be ok until they are definitely ok. Rationalise the heck out of it to get you through until you know for certain she has a bad case.
Burn rubber =/= warp speed
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#3405 User is offline   QuickTidal 

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Posted 20 September 2022 - 10:51 PM

View PostMezla PigDog, on 20 September 2022 - 08:54 PM, said:

Good luck QT. You hear lots of stories about vulnerable people sailing through a bout of covid. Remember that the bad outcomes are the outliers. But of course you don't know for sure anyone will be ok until they are definitely ok. Rationalise the heck out of it to get you through until you know for certain she has a bad case.


Thanks Mez. It means a lot.
"When the last tree has fallen, and the rivers are poisoned, you cannot eat money, oh no." ~Aurora
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#3406 User is offline   Azath Vitr (D'ivers 

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Posted 23 September 2022 - 01:10 PM

'COVID raises risk of long-term brain injury, large U.S. study finds

[...] Those who had COVID were 80% more likely to have seizures, 43% more likely to have mental health issues, such as anxiety or depression, 35% more likely to have headaches and 42% more likely to suffer movement disorders, such as tremors, compared with the control groups.'

COVID raises risk of long-term brain injury, large U.S. study finds

'even among those who were not hospitalized during the acute phase of COVID-19'

Long-term neurologic outcomes of COVID-19

Posted Image


'cerebrovascular disorders (ischemic stroke, TIA, hemorrhagic stroke, and cerebral venous thrombosis), cognition and memory (memory problems and Alzheimer’s disease), disorders of the peripheral nerves (peripheral neuropathy, paresthesia, dysautonomia, and Bell’s palsy), episodic disorders (migraine, epilepsy and seizures, and headache disorders), extrapyramidal and movement disorders (abnormal involuntary movements, tremor, Parkinson-like disease, dystonia, myoclonus), mental health disorders (major depressive disorders, stress and adjustment disorders, anxiety disorders, and psychotic disorders), musculoskeletal disorders (joint pain, myalgia, and myopathy), sensory disorders (Hearing abnormalities or tinnitus, vision abnormalities, loss of smell, and loss of taste), other neurologic or related disorders (dizziness, somnolence, Guillain-Barré syndrome, encephalitis or encephalopathy and transverse myelitis), and any neurologic outcome'

Risks and 12-month burdens of incident postacute COVID-19 composite neurologic outcomes by care setting of the acute infection compared with the historical control cohort
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#3407 User is offline   Renewed For 2 More Seasons 

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Posted 28 September 2022 - 06:10 AM


They came with white hands and left with red hands.
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#3408 User is offline   Azath Vitr (D'ivers 

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Posted 29 September 2022 - 02:55 PM

In Science:

'Big COVID-19 waves may be coming, new Omicron strains suggest

Emerging subvariants have hit on a combination of mutations that makes them more immune evasive than ever

[...] Despite their different origins, several of the new strains have chanced upon a similar combination of mutations to help scale the wall of immunity—a striking example of convergent evolution. They all have changes at half a dozen key points in the viral genome that influence how well neutralizing antibodies from vaccination or previous infection bind to the virus[...]

[...] infections with the variants trigger proportionally more of the wrong types of antibodies—those that bind tightly to the virus but don’t blunt its ability to infect cells. [...] “The scale of immune evasion has never been seen before, and the virus is still rapidly evolving,” [...] “It’s very bad.”

[...] “I think we’re going to learn a lot this winter.”'

Big COVID-19 waves may be coming, new Omicron strains suggest
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#3409 User is offline   Azath Vitr (D'ivers 

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Posted 30 September 2022 - 03:32 PM

This new drug could end the pandemic:

'NMT5, described in Nature Chemical Biology [...] when the virus is near, its path into human cells via the ACE2 receptor is blocked; in the absence of the virus, however, ACE2 can function as usual.

[...] "We're arming it with little molecular warheads that end up preventing it from infecting our cells; it's our revenge on the virus."

[...] In cell culture experiments testing how well the Omicron variant of SARS-CoV-2 can attach to human ACE2 receptors, the drug prevented 95% of viral binding. In hamsters with COVID-19, NMT5 decreased virus levels by 100-fold, eliminated blood vessel damage in the animals' lungs, and ameliorated inflammation. The drug also showed effectiveness against nearly a dozen other variants of COVID-19, including alpha, beta, gamma and delta strains.

[...] "We expect this compound would continue to be effective even as new variants emerge, because it doesn't rely on attacking parts of the virus that commonly mutate,"'

New drug has potential to turn SARS-CoV-2 virus against itself

But as with other new COVID-19 drug possibilities...

'Don't hold your breath. [...] Drugs get developed and approved fastest when there's strong government support behind them. [...] But that support has been dropping as much of the public, and many of their leaders, move on from COVID. [...] Two years ago, a new [...] drug might have been a no-brainer. Today it's a heavier lift. If a company takes a strong interest, a [...] therapy could go before federal regulators in a year or two.'

Scientists Identify Molecule That Can Kill COVID With 'Hugs' — but There's a Catch

... but if BA.2.75.2's ability to evade immunity from vaccines and infection with prior variants does cause a devastating late fall/winter surge, perhaps it will spur government support for the development and testing of these drugs (and intra-nasal and pan-coronavirus vaccines)....

This post has been edited by Azath Vitr (D'ivers: 30 September 2022 - 03:35 PM

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#3410 User is offline   Cyphon 

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Posted 01 October 2022 - 04:20 PM

Is there any set of reusable masks that are sufficient to protect you these days that are publicly available?

Conscious that they say the fabric ones are no good, and I don't like the disposable nature of the surgical masks.
Para todos todo, para nosotros nada.

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#3411 User is offline   Azath Vitr (D'ivers 

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Posted 01 October 2022 - 04:44 PM

View PostCyphon, on 01 October 2022 - 04:20 PM, said:

Is there any set of reusable masks that are sufficient to protect you these days that are publicly available?

Conscious that they say the fabric ones are no good, and I don't like the disposable nature of the surgical masks.


Elastomeric P100 masks:

Amazon.com: GVS SPR457 Elipse P100 Dust Half Mask Respirator with replaceable and reusable filters included, blue, m/l size

A Clunky, Reusable Mask May Be the Answer to N95 Waste - The New York Times (nytimes.com)

Even with the valve, elastomeric P100 masks provide other people with protection similar to that of a surgical mask, while providing you with better protection than an N95 mask (provided it fits well enough---but elastomeric masks adapt more to the contours of your face, so they're more likely to fit; make sure your glasses don't fog up).
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