[Azath Vitr (D'ivers]

'Stocks surge as COVID drug hope outweighs dismal economic data'

'Fauci gives his blessing to remdesivir

The result from Gilead's (NASDAQ:GILD) trial of remdesivir is "quite good news," says "President" Anthony Fauci, with the data showing "clear cut significant positive effect in diminishing the time to recovery." The FDA, he says, is working with Gilead on the availability of the drug.

[...] The primary endpoint was time to improvement, with those on remdesivir showing that in 11 days, and those on placebo 15 days.

The mortality rate on remdesivir was 8% vs. 11% for those on placebo.

[...] The independent Data Monitoring Committee informed him that remdesivir's clinical benefit was "clear-cut" and highly statistically significant (p<0.001). The drug's mortality benefit, while numerically better, is not yet statistically significant. Remdesivir represents a new standard-of-care for COVID-19.'
https://seekingalpha...g-to-remdesivir

'The Food and Drug Administration is likely to issue an emergency approval for remdesivir, a senior administration official told The New York Times. [...]

An emergency authorization by the F.D.A. is not the same as a formal drug approval by the agency. When the federal government declares a public health emergency, the F.D.A. can approve certain drugs or tests to address the emergency if there are no other alternatives. That is the case with the coronavirus, since no drugs have been proven to be effective against the virus.'

https://www.nytimes....ses-deaths.html

Wonder how much control Trump has over the F.D.A.'s emergency approvals....

'Nano cap Capricor Therapeutics (CAPR +180.5%) is up big on a whopping 69x surge in volume in reaction to new data on lead candidate CAP-1002, an off-the-shelf cardiac cell therapy, in severely ill COVID-19 patients.

Six patients were treated on a compassionate care basis. All were suffering from acute respiratory distress syndrome and five were on mechanical ventilator support.

All patients have survived. Four of the five patients on mechanical ventilation were successfully weaned off support within one-to-five days following infusion. The remaining patient remains on mechanical ventilation. The sixth patient is receiving supplemental oxygen and is clinically stable.

[...] The FDA has signed off on expanding the access protocol to include up to 20 additional COVID-19 patients.'

https://seekingalpha...nus-19-patients

This post has been edited by Azath Vitr (D'ivers: 29 April 2020 - 10:05 PM

[Lady Bliss]

Briar King, on 29 April 2020 - 05:49 PM, said:

I’m kinda crying inside cause I know I’m gonna be fucked for a awhile longer. Each time that shutdown gets extended I get bent further over. I’d a been Golden right now if my appointment had been a day earlier. I just need the dentist already to be back open. Don’t want to waste his time and look like a bitch by pulling an emergency move but it really hurts. I’m sure I ll be one of the first reschedules anyway since I was og on shutdown day so hopefully I can get in May if the 15th is the last extension.

Only 360 ish new cases popped up.

You need to make it an emergency then! Sorry you’re not feeling well.

[Cause]

If it doesn’t improve mortality what does it matter

[Malankazooie]

In my state we've gone to a 'safer at home' initiative, which is a relaxing of restrictions in place. There are a number of benchmarks and all that, but in short, people are going out now. So I went out this morning and decided to get a coffee at a Starbucks drive through. The line was ridiculously long. And people are mental now. A lady, in line driving a mini-van, decided she didn't want to wait any longer and she straight up drove her mini van over the curb to get out. She almost high centered her van on the curb and got stuck. She drove right over the curb in front of me and I could see she had that awkward, shit eating grin that advertised how big a mistake she knew she made, but she hit the gas, with awful sound of concrete grinding, sparks flying and tires squealing and high tailed it out of there. I hope people who go out and think things are going to be the way the were take a beat and reset their brains and adjust their expectations accordingly.

[Tsundoku]

Was only the drive-through operating? Couldn't people go in and get takeaway?

[Primateus]

Briar King, on 29 April 2020 - 05:49 PM, said:

I'm kinda crying inside cause I know I'm gonna be fucked for a awhile longer. Each time that shutdown gets extended I get bent further over. I'd a been Golden right now if my appointment had been a day earlier. I just need the dentist already to be back open. Don't want to waste his time and look like a bitch by pulling an emergency move but it really hurts. I'm sure I ll be one of the first reschedules anyway since I was og on shutdown day so hopefully I can get in May if the 15th is the last extension.

Only 360 ish new cases popped up.

If a tooth has gotten bad enough that it hurts like you're describing, then it's an emergency. Because it will not get better on its own, it will only get worse.

[Malankazooie]

Tsundoku, on 30 April 2020 - 07:06 AM, said:

Was only the drive-through operating? Couldn't people go in and get takeaway?

Walk in to for pick up orders are available, sure. In fact, most restaurants offer curb side service throughout the shelter in place. But I guess people feel safer picking up their orders from a drive through window. It's an odd thing to get used to, because now a popular thing is for the order to be placed on a tray and held out for the customer to grab. It's a strange new mindset to get used to.

[Macros]

[QuickTidal]

 w0nohaewbwv41.jpg (37.69K)
Number of downloads: 1

[Aptorian]

So it does work!

[Obdigore]

It's kind of funny, my state has one major city, and a couple of smaller city/towns.

The major city, with all the population density, was of course the initial hot spot, and people started to take it seriously. Now new cases in the large city/population density area is reducing, but the cases in the sparsely populated areas are exploding, and people in those areas are refusing to wear masks (part of the state of emergency is you have to wear a mask anywhere you could reasonably be expected to pass within 6 feet of someone you don't live with) and some business owners are posting signs stating anyone in their store wearing a mask will be told to leave and not helped.

And so we will all need to continue as much self-quarantine as we can, because these science deniers are getting sicker and sicker and using up resources that could help people who actually attempted to do what is expected of members of a community.

The best analogy I heard was thus:
Imagine you have 50 people in a pool. There is a sign that says 'no peeing in the pool'. 45 people follow that rule to make it better for everyone. 5 don't, so now everyone is covered in piss.

The sparsely populated part of the state has a number of meat packing/processing plants, which are all starting to shut down because most of their workers are sick. This is also happening in the midwest, according to people I work with that live out there.

Get ready for meat shortages in the US.

[Gorefest]

Don't think your analogy is entirely valid, although I know what you mean and I'm just being an annoying pedant here. The idea behind social distancing is that, if enough people do it, as long as you get the R number (value indicating the number of people that on average are infected by one person) below 1, the infection rate will drop. Similar to vaccination strategies. You don't need everyone to get vaccinated, as long as you have a large enough pool covered to ensure that each infected person on average spreads it to less than one other person. So a more accurate analogy I guess would be a tandem skydive where the 'passenger' gets to pull the string. As long as the majority of them pull it, on the whole it will remain a fun event. Sort of.

Maybe not the greatest analogy either, granted. I will have another think.

[Kanese S's]

Obdigore, on 30 April 2020 - 02:22 PM, said:

It's kind of funny, my state has one major city, and a couple of smaller city/towns.

The major city, with all the population density, was of course the initial hot spot, and people started to take it seriously. Now new cases in the large city/population density area is reducing, but the cases in the sparsely populated areas are exploding, and people in those areas are refusing to wear masks (part of the state of emergency is you have to wear a mask anywhere you could reasonably be expected to pass within 6 feet of someone you don't live with) and some business owners are posting signs stating anyone in their store wearing a mask will be told to leave and not helped.

And so we will all need to continue as much self-quarantine as we can, because these science deniers are getting sicker and sicker and using up resources that could help people who actually attempted to do what is expected of members of a community.

The best analogy I heard was thus:
Imagine you have 50 people in a pool. There is a sign that says 'no peeing in the pool'. 45 people follow that rule to make it better for everyone. 5 don't, so now everyone is covered in piss.

The sparsely populated part of the state has a number of meat packing/processing plants, which are all starting to shut down because most of their workers are sick. This is also happening in the midwest, according to people I work with that live out there.

Get ready for meat shortages in the US.

This is so predictable yet also frustrating.

Also apparently some companies like Budweiser and police departments in Illinois have come up with this galaxy brain idea:



Hoping they don't bring this stupidity here. Because I'm not fucking touching my mask once it's on right.

[Obdigore]

Gorefest, on 30 April 2020 - 04:11 PM, said:

Don't think your analogy is entirely valid, although I know what you mean and I'm just being an annoying pedant here. The idea behind social distancing is that, if enough people do it, as long as you get the R number (value indicating the number of people that on average are infected by one person) below 1, the infection rate will drop. Similar to vaccination strategies. You don't need everyone to get vaccinated, as long as you have a large enough pool covered to ensure that each infected person on average spreads it to less than one other person. So a more accurate analogy I guess would be a tandem skydive where the 'passenger' gets to pull the string. As long as the majority of them pull it, on the whole it will remain a fun event. Sort of.

Maybe not the greatest analogy either, granted. I will have another think.

The spread ratio for infected person in the less inhabited part of the state is over 1.10. In the part with the much higher population density it's gone down to under .7, from the metrics I have access to.

My analogy is more in regards to the closing of businesses - if we were firmly on a downward trend at .7 or so, we could actually extrapolate when we could talk about reopening stuff, but with a rate of over 1, we're still on that ugly upward slope.

[Puck]

Obdigore, on 30 April 2020 - 02:22 PM, said:

It's kind of funny, my state has one major city, and a couple of smaller city/towns.

The major city, with all the population density, was of course the initial hot spot, and people started to take it seriously. Now new cases in the large city/population density area is reducing, but the cases in the sparsely populated areas are exploding, and people in those areas are refusing to wear masks (part of the state of emergency is you have to wear a mask anywhere you could reasonably be expected to pass within 6 feet of someone you don't live with) and some business owners are posting signs stating anyone in their store wearing a mask will be told to leave and not helped.

One butcher shop tried that over here. The police showed up and reminded him there's a 5000 Euro fine for the first offence for businesses that don't comply. Dude quickly changed his mind.

Kanese S, on 30 April 2020 - 04:35 PM, said:

Also apparently some companies like Budweiser and police departments in Illinois have come up with this galaxy brain idea:



Hoping they don't bring this stupidity here. Because I'm not fucking touching my mask once it's on right.

That's my new contender for "stupidest idea of 2020". Good thing Germans are on average not too friendly anyway. Not that that makes them smarter, going by all the face touching and mask-adjusting I'm seeing every time I stick my nose out the door. I've now found the perfect combo of fabric, elastic bands and mask shape for me and am pleasantly surprised that black masks and dead stares seem to have a nice "stay the fuck away away from me, heathen" kind of effect and I'm NOT touching that mask until I'm back home once it's on.

[Aptorian]

Denmark has been a lot more lax in terms of precautions. Nobody's wearing masks and many places don't even have hand sanitizer.

[QuickTidal]

Toronto is utterly filled with masks. I see more people with them than without them.

This post has been edited by QuickTidal: 30 April 2020 - 06:02 PM

[Kanese S's]

Puck, on 30 April 2020 - 05:19 PM, said:

Obdigore, on 30 April 2020 - 02:22 PM, said:

It's kind of funny, my state has one major city, and a couple of smaller city/towns.

The major city, with all the population density, was of course the initial hot spot, and people started to take it seriously. Now new cases in the large city/population density area is reducing, but the cases in the sparsely populated areas are exploding, and people in those areas are refusing to wear masks (part of the state of emergency is you have to wear a mask anywhere you could reasonably be expected to pass within 6 feet of someone you don't live with) and some business owners are posting signs stating anyone in their store wearing a mask will be told to leave and not helped.

One butcher shop tried that over here. The police showed up and reminded him there's a 5000 Euro fine for the first offence for businesses that don't comply. Dude quickly changed his mind.

Kanese S, on 30 April 2020 - 04:35 PM, said:

Also apparently some companies like Budweiser and police departments in Illinois have come up with this galaxy brain idea:



Hoping they don't bring this stupidity here. Because I'm not fucking touching my mask once it's on right.

That's my new contender for "stupidest idea of 2020". Good thing Germans are on average not too friendly anyway. Not that that makes them smarter, going by all the face touching and mask-adjusting I'm seeing every time I stick my nose out the door. I've now found the perfect combo of fabric, elastic bands and mask shape for me and am pleasantly surprised that black masks and dead stares seem to have a nice "stay the fuck away away from me, heathen" kind of effect and I'm NOT touching that mask until I'm back home once it's on.

I mainly wear bandanas because they cover my beard as well, and I also find that I tend to adjust them less and my glasses don't fog up as much. A red or black bandana does send a similar message. I'm mainly wanting to avoid accidentally being a transmission vector.

It is funny, though, going into the bank or the grocery store looking like an olde tymey train robber.

[QuickTidal]

I'm about to blow all your minds...I have a Season 2 SURVIVOR buff that I wear as my mask (I don't have access to proper masks as they are still sold out and my mother-in-law's PSW's gets all the ones we do get our hands on because she's most at risk)...

[Puck]

Kanese S, on 30 April 2020 - 06:02 PM, said:

I mainly wear bandanas because they cover my beard as well, and I also find that I tend to adjust them less and my glasses don't fog up as much. A red or black bandana does send a similar message. I'm mainly wanting to avoid accidentally being a transmission vector.

It is funny, though, going into the bank or the grocery store looking like an olde tymey train robber.

Nice one. I'd probably done the same but my mom (and by extension, me as well, as she keeps taking on more work than she can handle) actually sew and sell the fabric masks since they're now mandatory on public transport and inside shops here, so I can basically pick and choose what works best for me and doesn't fog up my glasses too much.