'Two decades of Alzheimer's research may be based on deliberate fraud that has cost millions of lives
[...] Over the last two decades, Alzheimer's drugs have been notable mostly for having a 99% failure rate in human trials. [...] now we have a good idea of why. Because it looks like the original paper that established the amyloid plaque model as the foundation of Alzheimer's research over the last 16 years might not just be wrong, but a deliberate fraud.
[...] As
Science reports[...] There's good evidence that for the last 16 years, almost everyone has had the wrong idea about the cause of Alzheimer's. Because of a fraud.
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Two decades of Alzheimer's research may be based on deliberate fraud that has cost millions of lives
'Large systematic review finds no evidence for the serotonin hypothesis of depression
[...] Decades of literature has argued that depression results from abnormalities in serotonin, a neurotransmitter involved in numerous psychological and physiological processes. This has served as the basis for the use of Selective Serotonin Reuptake Inhibitor (SSRI) antidepressants. That depression is caused by a chemical imbalance in the brain has widespread support from researchers, health care practitioners, and the general public. The seeming efficacy of SSRIs is believed to provide support for the involvement of serotonin in depression. Other explanations have suggested that antidepressants enhance a placebo effect or generally blunt emotion.
[...] "the major strands of research on serotonin shows there is no convincing evidence that depression is associated with, or caused by, lower serotonin concentrations or activity." Most studies revealed no differences in serotonin activity between people with depression and without. As well, the methods of reducing serotonin availability via tryptophan depletion did not lower mood among participants. Further, genetic studies reject a link between genotypes relating to the serotonin system and depression.
The researchers add, "The idea that depression is the result of a chemical imbalance also influences decisions about whether to take or continue antidepressant medication and may discourage people from discontinuing treatment, potentially leading to lifelong dependence on these drugs."
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Large systematic review finds no evidence for the serotonin hypothesis of depression
'[...] Scorched Fields Across Europe
[...] compounding problems for food producers, who were already reeling from frosts, hail and drought in the first half of the year.'
Supply Chain Latest: bread inflation in US and heat waves across Europe
'Biden Is All Talk as Fires Take Over the American West
[...] fire outlook across the American West is bleak, part of a global pattern of escalating droughts, the drying out of the land in periods of abnormal heat, and the consequent outbreak of devastating fires.'
Biden Is All Talk as Fires Take Over the American West