'the Biden administration's technological optimism is paired with an institutional conservatism: Too many Washington agencies proved too cautious during the pandemic, and little has been done to make them more daring.
[...] I have spoken to some of the researchers working on universal coronavirus vaccines and I'm stunned by how little help they're getting. One described months of delay trying to find the monkeys needed for trials. You might think the U.S. government, with all its power and might, would name a point person that the teams working on these vaccines could call if they needed something, anything. Instead, many of our most brilliant virologists spend their work days trying to find lab animals and figure out how to conduct due diligence of manufacturing facilities.
And I have been puzzled by the Biden administration's disinterest in building on the Trump administration's central success: The Operation Warp Speed program that sped the vaccines into development. We could have Warp Speeds for so much more (and we are far from done with vaccines). I've asked this question of top Biden staffers, and I cannot say the answers I've heard have made much sense. I suspect the problem here relates more to crediting the Trump administration than with the possibilities of the Warp Speed program. [...] But that doesn't explain why Biden hasn't launched Warp Speed-like policies under a new brand.'
What Joe Biden Knows That No One Expected Him To
'We urgently need such an accelerated initiative now for nasal vaccines. [...] As the virus continues its accelerated ability to evade our immune response and increase its transmissibility, we urgently need to achieve population-wide respiratory mucosal immunity [to stop transmission and infection].'
Operation Nasal Vaccine—Lightning speed to counter COVID-19 | Science Immunology
... what does Biden do instead? Goes on national television to declare that the pandemic is 'over'. US booster rates are already worse than Iran and Rwanda....
'Wish this was true. What's over is
@POTUS's and our government's will to get ahead of it, with magical thinking on the new bivalent boosters. Ignores #LongCovid, inevitability of new variants, and our current incapability for blocking infections and transmission
only 1 of 3 Americans have had any booster shot. A proclamation "it's over" is not going to help that
Remember when the pandemic was over in June 2021, when we were down to <12,000 (real number) confirmed cases per day, and Independence was declared?'
Eric Topol on Twitter
China approved an inhalable vaccine a few weeks ago that seems to be effective at stopping transmission. Russia claims to have one as well.
'There's ample evidence from multiple studies that mucosal IgA antibodies are what will be needed to help block infections and transmission, such as this NEJM new report with 60-80% reduction of breakthrough infections (and reduced viral load, higher Ct, Tables below) as a function of mucosal IgA antibodies [...] encouraging data from CanSino's newly approved inhaled vaccine vs Omicron is a solid precursor for the many programs that are in advanced clinical trials.
Ground Truths
There's probably going to be a massive BA.2.75.2 surge this winter---most likely considerably larger than last year's (much greater immune escape + much more contagious).
If the titanic surge starts shortly after the midterm elections I imagine many will interpret it as punishment from Go*. Especially if Democrats win. As if Trump fanatics needed any more inspiration....