'Light that kills bacteria: Alternative to antibiotics
The World Health Organisation is convinced that one of the greatest threats to humanity is the rapidly growing resistance of bacteria to antibiotics due to their uncontrolled use. One Russian scientific project[...] offers a possible solution to this problem.
Scientists believe that one solution to this global challenge could be the development of antibacterial photodynamic therapy (aPDT). According to numerous studies, pathogens cannot develop resistance to this type of treatment.
The antimicrobial effect of aPDT is based on the use of special substances, photosensitisers, which are injected into the body and irradiated with light using a special emitter in the course of treatment. The resulting light energy is transmitted to oxygen molecules and transforms them into an active form that fights the infection.
[...] synthetic polycationic bacteriochlorins as photosensitisers. Unlike most antibiotics that target only one type of bacteria, these compounds have a universal effect in aPDT treatment. Scientists believe that this will eliminate the need to identify the type of bacterial threat in clinical practice, thereby saving time and resources.
According to the WHO's guidelines, any drug that reduces the number of active pathogen cells by at least 103 times is considered to be an effective antibacterial agent. [...] the bacteriochlorins they use exceed this figure by at least 10 times.
[...]
First of all, this efficiency is achieved due to the potent ability of bacteriochlorins to absorb light and subsequently transfer energy to the oxygen present in the body. The rapid destruction of bacteria is ensured by the effect of the active form of oxygen "charged" with energy from the photosensitiser.
[...] bacteriochlorins effectively absorb light in the near-infrared range. The scientists explained that this region of the spectrum contains the so-called "transparency window of biological tissues," meaning that light of this wavelength can penetrate much deeper into the tissues of the body.
[...] ""The experiments showed high efficiency of bacteriochlorins against strains of antibiotic-resistant bacteria
[...] This greatly increases our chances of success in real clinical trials," [...]
"These compounds can already be used at the current stage of testing for technical purposes—for example, for effective surface disinfection in hospitals. We hope to subsequently develop a medicinal product based on bacteriochlorins for use in human and veterinary medicine"'
https://phys.org/new...ntibiotics.html
This post has been edited by Azath Vitr (D'ivers: 18 February 2021 - 03:42 AM